Conservative fertility-sparing surgical treatment of invasive epithelial ovarian cancer: when is it acceptable?
نویسنده
چکیده
The disadvantages of the reviewed studies dealing with fertility-sparing conservative surgery in EOC reported during the last 20 years are inherent in their retrospective nature. Many of the studies include a limited number of patients. The follow-up periods in these studies vary greatly and in some it is not indicated at all. Outcome is often given as the number of patients with recurrence or the number of patients alive at the end of follow-up and not as the probability of survival. The percentage of serous and mucinous carcinoma in stage I EOC in young patients is about equal. Yet, in many of the studies the rate of patients with mucinous carcinomas treated conservatively exceeds by far that of other histological types and is as high as 62-76%, while serous tumors comprise only a small proportion of the cases. In several studies the histological type is not given at all. An assessment of outcome according to histologic type of the tumor was not done in many of the studies, probably because of the limited number of patients. In some of the studies adjuvant chemotherapy was administered after conservative surgery. However, how this affected the outcome was not assessed. Nevertheless, it seems that the presented data indicate that fertility-sparing conservative surgery in stage IA grade 1 (and possibly grade 2) EOC does not significantly compromise survival and allows future fertility. Although favorable results have been reported in many studies that included conservatively treated patients with higher stage and grade, their number is too small to draw any conclusion.
منابع مشابه
O-29: Fertility Sparing Treatments in Young Patients with Gynecological Cancers: A Large Iranian Experience and A Literature Review
Background: The marriage age has been increasing recently throughout the world and researches have shown an increased rate of gynecological cancers among young women. Therefore, fertility sparing in these patients is an important point and many works have been done on conservative management in young women with gynecological cancer. Materials and Methods: In this study, we report our experience...
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ورودعنوان ژورنال:
- The Israel Medical Association journal : IMAJ
دوره 15 2 شماره
صفحات -
تاریخ انتشار 2013